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                <full_title>The Journal of Phytopharmacology</full_title>
                <abbrev_title>J Phytopharmacol</abbrev_title>
                <issn media_type="electronic">2320480X</issn>
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                  <month>7</month>
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                  <year>2026</year>
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                  <volume>15</volume>
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                  <title>In-vivo anthelmintic efficacy of polyherbal formulation and vidangadi churna on gastrointestinal nematodes of sheep</title>
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                  <person_name sequence="first" contributor_role="author">
                    <given_name>Sylvia Hatngeineng</given_name>
                    <surname>Baite</surname>
                    <affiliations>
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                        <institution_name>Department of Veterinary Parasitology, Karnataka Veterinary Animal and Fisheries Sciences University (KVAFSU), Shivamogga – 577204, Karnataka, India</institution_name>
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                    <ORCID>https://orcid.org/0009-0000-8657-9057</ORCID>
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                    <given_name>Pradeep Banagere</given_name>
                    <surname>Shekharappa</surname>
                    <affiliations>
                      <institution>
                        <institution_name>Department of Veterinary Parasitology, Karnataka Veterinary Animal and Fisheries Sciences University (KVAFSU), Shivamogga – 577204, Karnataka, India</institution_name>
                      </institution>
                    </affiliations>
                    <ORCID>https://orcid.org/0009-0008-3319-0206</ORCID>
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                  <person_name sequence="additional" contributor_role="author">
                    <given_name>Ananda Konanur</given_name>
                    <surname>Javaregowda</surname>
                    <affiliations>
                      <institution>
                        <institution_name>Department of Veterinary Parasitology, KVAFSU, Veterinary College, Hebbal - 560024, Bengaluru, India</institution_name>
                      </institution>
                    </affiliations>
                    <ORCID>https://orcid.org/0000-0003-1013-8057</ORCID>
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                    <given_name>Dhanalaskhmi</given_name>
                    <surname>Hanumappa</surname>
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                      <institution>
                        <institution_name>Department of Veterinary Parasitology, KVAFSU, Veterinary College, Hebbal - 560024, Bengaluru, India</institution_name>
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                    <ORCID>https://orcid.org/0000-0003-3005-3106</ORCID>
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                    <given_name>Sharada</given_name>
                    <surname>Ramakrishnaiah</surname>
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                      <institution>
                        <institution_name>Department of Veterinary Microbiology, KVAFSU, Veterinary College, Hebbal – 560024, Bengaluru, India</institution_name>
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                    <ORCID>https://orcid.org/0000-0003-2580-9714</ORCID>
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                  <person_name sequence="additional" contributor_role="author">
                    <given_name>Yathish Hirenallur</given_name>
                    <surname>Maheshwarappa</surname>
                    <affiliations>
                      <institution>
                        <institution_name>Department of Animal Genetics &amp; Breeding, KVAFSU, Veterinary College, Hebbal – 560024, Bengaluru, India</institution_name>
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                    </affiliations>
                    <ORCID>https://orcid.org/0000-0002-0991-4883</ORCID>
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                  <person_name sequence="additional" contributor_role="author">
                    <given_name>Kumar Seethakempanahalli</given_name>
                    <surname>Kempanna</surname>
                    <affiliations>
                      <institution>
                        <institution_name>Transdisciplinary University, Yelahanka, Bengaluru - 560119, Karnataka, India</institution_name>
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                  <person_name sequence="additional" contributor_role="author">
                    <given_name>Rudraswamy Mathad</given_name>
                    <surname>Shivamurthaiah</surname>
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                      <institution>
                        <institution_name>Livestock Research and Information Centre (Amrithmahal), Konehalli, Tiptur - 572201, Karnataka, India</institution_name>
                      </institution>
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                    <ORCID>https://orcid.org/0000-0002-2555-5243</ORCID>
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                  <jats:p>Background: The use of synthetic anthelmintic alone is not effective for the long-term management of gastrointestinal parasites in livestock as it may lead to development of anthelmintic resistance, residue risk and affordability, noting all these problems use of herbal anthelminthics is gaining more importance. Objective: The anthelmintic property of polyherbal formulation and vidangadi churna were evaluated against gastrointestinal nematodes of sheep. Materials and Methods: Eighty clinically suspected sheep were randomly divided into 8 groups of 10 animals each. Group I and II were dosed with fenbendazole at the rate of 5 mg/kg body weight [Recommended dose] and 15 mg/kg body weight [dose which farmers are using at field level] orally, single dose. While group III, IV and V were dosed with polyherbal formulation in equal proportion according to the dose @30g, 60g and 120g per animal orally, single dose and group VI, VII and VIII were administered different doses of vidangadi churna viz., 12.5g, 25g and 37.5g per animal, orally, single dose. Faecal samples from each individual in all groups were collected and quantitative estimation of faecal sample was done on day 0 (pre -treatment) and 14 days after the treatment. Results: Using faecal egg count reduction test (FECRT), on 14th day post treatment polyherbal formulation showed an efficacy of 54.80 per cent, 70.19 per cent, and 87.03 percent at a dose rate of 30, 60 and 120 gram per animal respectively, while vidangadi churna showed an efficacy of 90.78 per cent, 82.44 per cent and 70.20 per cent at a dose rate of 37.5g, 25g and 12.5g per animal respectively. As per World association for advancement of veterinary Parasitology (WAAVP), fenbendazole was found to be resistant in both the doses administered in the present study. Conclusion: Thus, the herbal product used in the current study can be employed as an alternate to synthetic anthelmintics.</jats:p>
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                  <month>7</month>
                  <day>6</day>
                  <year>2026</year>
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                  <first_page>163</first_page>
                  <last_page>167</last_page>
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