none 10.31254/phyto.2026.15307 BioMed Research Publishers BioMed Research Publishers 16195 197648543 316921 20260706150857671 10.31254 2026-07-06T15:09:17Z 2026-07-06T15:09:16Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 7 6 2026 15 3 Kouakou S. Landry Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire https://orcid.org/0000-0002-6101-4110 Adehouni Y. Adebo Laboratoire de Pharmacologie, Pharmacie Hospitalière, physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire https://orcid.org/0000-0002-5104-464X Kamagate Amara Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire https://orcid.org/0009-0006-8464-1324 Paul Maomy Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubreka, Guinea https://orcid.org/0009-0001-6150-1197 Djadji A.T Lenoir Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire https://orcid.org/0000-0002-7867-4043 Effo K. Etienne Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire https://orcid.org/0009-0009-7187-2651 Kouakou S. Gisele Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire Irie N.G Genevieve Laboratoire de Pharmacologie, Pharmacie Hospitalière, Physiologie Humaine, Sémiologie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire Background: Diabetes is a major health challenge, particularly in low-income countries. Okra (Abelmoschus esculentus), widely consumed in Côte d'Ivoire, is traditionally used to help reduce blood sugar. Objective: This study aimed to evaluate the antihyperglycemic effect of an infusion of dried Okra seeds in rats, both alone and in combination with conventional antidiabetics (metformin and gliclazide). Materials and Methods: A qualitative and quantitative phytochemical characterization was performed. The antihyperglycemic activity was tested in vivo on Wistar rats subjected to an oral glucose tolerance test (OGTT). Eight groups of rats with six (6) animals per experimental group were constituted: controls, treated with okra alone (195 mg/kg), metformin (10 mg/kg), gliclazide (100 mg/kg), and combinations of Okra 195 mg/kg + metformin 10 mg/kg and okra 195 mg/kg + gliclazide 100 mg/kg. Results: Administration of the Okra seed infusion (195 mg/kg) alone, which contained flavonoids, alkaloids, tannins, sterols, polyterpenes, and quinones, was not capable reducing orally induced hyperglycemia. Its combination with metformin (10 mg/kg) was safe, bringing blood glucose to 0.85 g/dL at T120, while with gliclazide (100 mg/kg), marked hypoglycemic effect, with glucose levels dropping to -31.15% below baseline at 120 min. Conclusion: The infusion of dried Okra grains lacks significant antihyperglycemic potential on its own. Its combination with metformin appears beneficial in a nutritional approach. Great caution is advised with concomitant use of sulfonylureas due to the risk of hypoglycemia. Further studies are recommended to explore molecular mechanisms and long-term effects. 7 6 2026 156 162 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2026.15307 https://phytopharmajournal.com/articles/abstracts/916/year=2026&vol=15&issue=3