none 10.31254/phyto.2026.15302 BioMed Research Publishers BioMed Research Publishers 16195 197282200 316921 20260630015746554 10.31254 2026-06-30T01:57:52Z 2026-06-30T01:57:52Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 6 24 2026 15 3 Arastu Kumar Department of Veterinary Pharmacology & Toxicology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0009-0001-8652-6753 Rajesh Mandil Department of Veterinary Pharmacology & Toxicology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0000-0002-5027-3758 Amit Kumar Department of Animal Biotechnology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0000-0003-3767-4343 Shikha Chaudhary Department of Veterinary Pharmacology & Toxicology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0009-0003-3992-8885 Vikas Jaiswal Department of Veterinary Pathology, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0000-0001-5457-3419 Mullakkalparambil Velayudhan Jithin Department of Veterinary Medicine, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut-250110, Uttar Pradesh, India https://orcid.org/0000-0003-2946-555X Background: Chlorantraniliprole is a widely used anthranilic diamide insecticide considered relatively safe for non-target organisms; however, prolonged exposure may induce hepatic and renal toxicity. Curcumin, a natural polyphenolic compound derived from Curcuma longa, possesses potent antioxidant and tissue-protective properties. Objective: The present study was undertaken to evaluate the ameliorative potential of curcumin against chlorantraniliprole-induced hepato-renal toxicity following 28 days of oral exposure in Wistar rats. Materials and Methods: Forty adult male Wistar rats were randomly divided into five groups (n=8). Group A served as the normal control and received distilled water, while Group B received corn oil as vehicle control. Group C was administered curcumin (100 mg/kg), Group D received chlorantraniliprole (250 mg/kg), and Group E received chlorantraniliprole (250 mg/kg) along with curcumin (100 mg/kg) orally for 28 days. Liver and kidney function biomarkers were estimated, followed by histopathological examination of hepatic and renal tissues. Results: Chlorantraniliprole administration caused marked alterations in liver and kidney function biomarkers. AST and ALT levels increased from 91.25±7.12 U/L and 48.62±3.34 U/L in the control group to 122.50±8.10 U/L and 65.50±7.09 U/L, respectively, in chlorantraniliprole-treated rats. Similarly, blood urea nitrogen (BUN), creatinine, and uric acid levels increased to 78.13±13.81 mg/dl, 0.83±0.06 mg/dl, and 1.38±0.18 mg/dl, respectively, compared to control values of 37.25±8.22 mg/dl, 0.73±0.03 mg/dl, and 1.08±0.10 mg/dl. Histopathological examination revealed congestion, bile duct epithelial proliferation, hepatocellular degeneration, necrosis, and periportal fibroplasia in the liver, while kidneys showed congestion, focal hemorrhage, glomerular cellular proliferation, tubular dilatation, and tubular degeneration. Co-administration of curcumin significantly ameliorated these alterations, reducing AST and ALT levels to 114.13±6.67 U/L and 59.12±4.03 U/L, respectively, and improving renal biomarkers and tissue architecture toward normal. Conclusion: The findings of the present study demonstrate that curcumin exerts protective effects against chlorantraniliprole-induced hepato-renal toxicity, possibly through its antioxidant and free radical scavenging properties. Curcumin may therefore serve as a promising therapeutic agent for mitigating pesticide-induced organ damage. 6 24 2026 211 218 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2026.15302 https://phytopharmajournal.com/articles/abstracts/910/year=2026&vol=15&issue=3