none 10.31254/phyto.2025.14401 BioMed Research Publishers BioMed Research Publishers 16195 184331097 316921 20251025020154379 10.31254 2025-10-25T02:01:57Z 2025-10-25T02:01:57Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 09 30 2025 14 4 Tharcitus Chilaka Onwudiwe https://orcid.org/0009-0006-3173-6530 Bede Chinedu Azudialu https://orcid.org/0009-0009-0269-4169 Ifeanyi Malachy Obi https://orcid.org/0000-0003-1100-9396 Ngozi Ukamaka Madubuogwu https://orcid.org/0000-0002-4410-5168 Emmanuel Onyebuchi Ogbuagu https://orcid.org/0000-0001-5731-1932 Background: Nociception (pain) and inflammation have adverse impact on health and socio-economic well-being of humans globally. Currently, synthetic opioids and NSAIDs are commonly used in management of pain and inflammation, but certain factors like unavailability, unaffordability and unwanted reactions, have limited their use as anti-nociceptive and anti-inflammatory agents. Natural plants are important source of new drugs for treatment of numerous human ailments, including pain and inflammation. Analysis of folklore herbal plants used in tradomedical management of pain and inflammation is a laudable and logical approach towards development of new therapy. Objective: The present work sought to evaluate the anti-nociceptive and anti-inflammatory activities of a folklore medicinal plant (Gongronema latifolium) in rodent models. Method: This was accomplished by using acetic acid (writhing) and formalin models in albino mice to test for anti-nociceptive activity, while carrageenan and histamine models in albino rats were used to test for anti-inflammatory activity. Result: The results of anti-nociceptive activity reveal that treatment with the leaf extract of Gomgronema latifolium when compared to negative control, produces significant (p<0.05) inhibition of nociception on acetic acid and formalin models. The results of anti-inflammatory activity also indicate significant (p<0.05) inhibition of inflammation on carrageenan and histamine models. Conclusion: The present work therefore, authenticates the folklore medicinal claim and existing scientific reports on Gongronema latifoliumas as an agent for management of pain and inflammation. We recommend further studies to identify the bioactive principle(s) responsible for the observed activities. 09 30 2025 208 214 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2025.14401 https://phytopharmajournal.com/articles/abstracts/829/year=2025&vol=14&issue=4