none 10.31254/phyto.2025.14308 BioMed Research Publishers BioMed Research Publishers 16195 182219656 316921 20250913114628951 10.31254 2025-09-13T11:46:35Z 2025-09-13T11:46:34Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 07 31 2025 14 3 Avishkar Zagday https://orcid.org/0000-0003-3934-8170 Vinay Upadhyay https://orcid.org/0009-0005-7179-8341 Background: Conventional antiepileptic treatments frequently fail to address postictal neuromuscular impairments, which include motor incoordination and muscle weakness, which are typical following epileptic episodes. This study uses a Pentylenetetrazole (PTZ) induced mouse seizure paradigm to assess the therapeutic potential of Plumbum metallicum, a homeopathic medicine, in reducing these impairments. Aim and Objectives: This study aims to evaluate the therapeutic potential of Plumbum metallicum in mitigating postictal neuromuscular deficits using a PTZ-induced murine seizure model. Motor coordination was assessed via the rotarod test, comparing the effects of Plumbum metallicum at 6C, 30C, and 200C potencies with diazepam and PTZ-only groups. Materials and Methods: Male albino Wistar mice were divided into six groups (n=6/group): Control, PTZ-only, Diazepam+PTZ, and three groups receiving Plumbum metallicum at 6C, 30C, and 200C potencies prior to PTZ administration. Treatments were given chronically for 14 days. Motor coordination was measured by Rota Rod test and statistical analysis by Dunnett's test and one-way ANOVA. Results: Plumbum metallicum improved rotarod performance in a dose-dependent way. When compared to the PTZ group, the 200C potency had statistically significant neuroprotective and motor-enhancing benefits, but the 6C potency exhibited little or even negative effects. Performance in the 200C group was similar to that of the diazepam-treated group, indicating similar effectiveness in fostering postictal motor recovery. Conclusion: The results indicate that Plumbum metallicum has a potency-dependent impact, with 200C showing the greatest effectiveness in alleviating postictal motor impairments. This is consistent with homeopathic principles, which indicate that larger potencies have more therapeutic potential. The study lays the groundwork for future clinical and mechanistic investigations into Plumbum metallicum's function in post-seizure recovery and emphasizes its potential as a neurotherapeutic agent. 07 31 2025 177 179 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2025.14308 https://phytopharmajournal.com/articles/abstracts/821/year=2025&vol=14&issue=3