none 10.31254/phyto.2025.14301 BioMed Research Publishers BioMed Research Publishers 16195 182218938 316921 20250913111828153 10.31254 2025-09-13T11:18:35Z 2025-09-13T11:18:34Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 07 31 2025 14 3 V. V. Rajesham V. Jyoshna G. Supriya Reddy T. Rama Rao Background: In the Indian medicinal system, Albizia lebbeck is known for its various therapeutic properties, including antiseptic, anti-dysenteric, anti-tubercular, anti-asthmatic, and anti-fertility effects, which have been historically linked to it. Objective: The objective of the present study was to evaluate the ethanolic extract of Albizia lebbeck pods (ALPE) for its protective effects against gentamicin-induced nephrotoxicity in rats. Materials and Methods: The rats were divided into five groups: one receiving normal saline, another receiving gentamicin at 100 mg/kg i.p., a third group treated with Cystone at 5 ml/kg p. o. for 8 days, and two groups receiving ALPE at doses of 200 mg/kg and 400 mg/kg p. o. for 21 days, alongside gentamicin for 8 days. Serum levels of protein, creatinine, urea, and blood urea nitrogen were measured. After treatment, kidneys were collected for histological analysis. Results: The gentamicin treatment led to nephrotoxicity, evidenced by significant changes in blood parameters. However, the concurrent administration of the ethanolic extract of Albizia lebbeck pods with gentamicin markedly improved all measured parameters. Histopathological examinations indicated a decrease in kidney damage when treated with the extract. Conclusion: The results suggest that the ethanolic extract of Albizia lebbeck pods may be effective in preventing gentamicin-induced nephrotoxicity. 07 31 2025 130 134 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2025.14301 https://phytopharmajournal.com/articles/abstracts/814/year=2025&vol=14&issue=3