none 10.31254/phyto.2025.14109 BioMed Research Publishers BioMed Research Publishers 16195 174147565 316921 20250327162658435 10.31254 2025-03-27T16:27:25Z 2025-03-27T16:27:19Z 2 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 3 23 2025 14 1 Ramesh Chandra Sharma https://orcid.org/0009-0000-8832-8219 Anupam Singha Roy https://orcid.org/0000-0003-4052-272X The genus Calotropis possesses two species Calotropis procera and Calotropis gigantea. Both species, stand out as important therapeutic plants because of the abundance of phytochemicals they contain, such as steroids and alkaloids, saponins glycosides, flavonoids, triterpenes, and anthraquinones. The various components found in different parts of both species contribute to their efficacy in treating a broad spectrum of health concerns, such as helminthic infections, diabetes, diarrhoea, malaria, inflammation, sterility, spasmodic disorders, cancer risks, and a variety of skin illnesses. This review critically examines and compares the phytochemical profiles and pharmacological activities of these two species, providing insights into their specific medicinal applications and efficacy. By consolidating current research, this review aims to guide future pharmacological studies and the development of herbal formulations based on Calotropis species. 3 23 2025 62 69 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2025.14109 https://phytopharmajournal.com/articles/abstracts/805/year=2025&vol=14&issue=1