none 10.31254/phyto.2024.13503 BioMed Research Publishers BioMed Research Publishers 16195 169316334 316921 20241223234131831 10.31254 2024-12-23T23:41:42Z 2024-12-23T23:41:39Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://www.phytopharmajournal.com/ 10 31 2024 13 5 Mayank https://orcid.org/0009-0005-3920-8874 Yogesh Kumar https://orcid.org/0009-0007-0174-414X Limonin (LM), a limonoid glycoside isolated from leaves, fruits, and seeds of citrus plants, belongs to the class of furanolactones [1]. Recently, LM has gained significant interest due to its multiple biological activities such as anti-inflammatory, antitumor, antimicrobial, and antifeedant activity. Lu et al. [2] demonstrated that pretreatment of LPS-induced microglial cells with LM substantially prohibited the formation of ROS and prevented the deposition of NO, PGE2, IL-1β, IL-6, and TNF-α [2]. Furthermore, LM significantly reduced the expressions of iNOS and COX-2 [3]. Their results indicated that LM inhibited inflammatory response through repressing the formation of ROS, accretion and discharge of cytokines, and activation of inflammatory mediators, suggesting its potential as a neuroprotective agent. 10 31 2024 359 360 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2024.13503 https://www.phytopharmajournal.com/assets/pdf_files/Vol13_Issue5_03.pdf