none 10.31254/phyto.2024.13411 BioMed Research Publishers BioMed Research Publishers 16195 164950753 316921 20240922115332928 10.31254 2024-09-22T11:53:41Z 2024-09-22T11:53:36Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://phytopharmajournal.com/ 8 31 2024 13 4 Mistu Tripura Bhupesh Kamdi Ranjit Ingole Maheshkumar Ingawale Prajakta Kuralkar Sunil Hajare Gold was used in the vedic era in India to enhance strength, potency and to combat the aging process in humans. It is one of the few metals which can be used at nano scale due to its resistance to oxidation. Considering the biological activity of gold, the present study was carried out to evaluate the effect of Lemon peel extract gold Nanoparticals (LPGNP) on As + Pb induced reproductive toxicity in rats. In present study twenty-four wistar rats were divided into four groups, group I served as control, group II, III, IV received co-exposure of Sodium Arsenate 13.8mg/kg and Lead acetate 116.4 mg/kg, p.o. daily for 14 days, followed by oral administration of LPGNP @10 and 20 mg/kg, to group III and IV, respectively for 6 weeks. At the end of experiment hematology, reproductive parameters and histopathology of testes was studied. The findings of study revealed significant alteration in hematobiochemical parameters, serum testosterone concentration, sperm motility, total sperm count and sperm viability in rats received As-Pb exposure whereas LPGNP administration caused marked improvement in reproductive parameters. In histopathology of testis, As + Pb caused degenerative changes of seminiferous tubules, and sloughing of spermatogenic cells. In LPGNP treated rats, minimal histopathological alterations were observed in testis. In conclusion LPGNP caused significant improvement in biochemical and sperm parameters and testosterone level in As + Pb induced reproductive toxicity in rats. 8 31 2024 341 344 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2024.13411 https://www.phytopharmajournal.com/assets/pdf_files/Vol13_Issue4_11.pdf