none 10.31254/phyto.2024.13209 BioMed Research Publishers BioMed Research Publishers 16195 160629331 316921 20240512122131292 10.31254 2024-05-12T16:21:40Z 2024-05-12T16:21:38Z 1 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://www.phytopharmajournal.com/ 4 30 2024 13 2 Imoh Emmanuel Ukoh https://orcid.org/0000-0002-5195-5873 Idongesit Bassey Umoh Enene Esu Ukpai Samuel Kelechi Mobisson https://orcid.org/0000-0002-7392-2976 Ikete Precious Whiskey Perowei Azosibe https://orcid.org/0009-0006-1228-5850 Azibaobom Karibi Ukrakpo Oghenemega Sophia https://orcid.org/0009-0008-0606-3084 Adienbo Emmemodi Nwadighi Objective(s): The therapeutic efficacy of FPO and vitamin E were studied against TPO induced derangements in some proteins in rats. Materials and Methods: 60 male albino rats (140-160g) weight range, grouped (n=10) as: Control, TPO, FPO, Vitamin E, TPO treated with FPO (TPO+FPO) and Vitamin E (TPO+ Vitamin E). TPO and FPO (15g each) mixed with 85g rat feed was used to prepare FPO and TPO diet. Vitamin E was administered 200mg/kg daily by oral gavage. Animals were fed for 4 weeks, while group 5 and 6 were further treated with FPO and Vitamin E for another 4 weeks. At the end of the experiment blood were collected from sacrificed rats via cardiac puncture and protein indices were analyzed using serum. Results: Sero-protein analysis revealed a significant reduction in total protein, albumin, globulin and albumin-globulin ratio in TPO compared to control, FPO and Vitamin E, but was significantly increased in TPO+FPO and TPO+ Vitamin E compared to TPO. Total protein was significantly increased in TPO+FPO compared to TPO+ Vitamin E, while globulin was significantly increased in TPO+ Vitamin E compared to TPO+FPO. Total bilirubin and unconjugated bilirubin were significantly increased in TPO compared to control, FPO and Vitamin E, but was significantly reduced in TPO+FPO and TPO+ Vitamin E compared to TPO. Total bilirubin was significantly reduced in TPO+FPO compared to TPO+ Vitamin E. Conjugated bilirubin was significantly reduced in TPO compared to control, FPO and Vitamin E, but was significantly increased in TPO groups treated with FPO and Vitamin E in relation to TPO. Conclusion: FPO and vitamin E displayed therapeutic efficacy in ameliorating protein derangements instigated by TPO consumption. 4 30 2024 154 159 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2024.13209 https://www.phytopharmajournal.com/assets/pdf_files/Vol13_Issue2_09.pdf