none 10.31254/phyto.2024.13204 BioMed Research Publishers BioMed Research Publishers 16195 160620941 316921 20240511110216784 10.31254 2024-05-11T15:02:29Z 2024-05-11T15:02:21Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://www.phytopharmajournal.com/ 4 30 2024 13 2 Anish Murtaja Alam Khan Nusrat Nabi Gholamreza Abdi Vineet Jain Dharmander Singh Ozair Alam Sayeed Ahmad Kailash Chandra https://orcid.org/0000-0002-4938-9622 Diabetes is a global health issue, impacting life expectancy and productivity. Pathogenesis of diabetes mellitus involves decreased functional beta cells, making beta cell replacement and regeneration a crucial area of research. However, current methods like whole pancreas transplant or stem cell-derived beta cells have limitations for diabetic patients. Exploring pharmacological approaches to stimulate regeneration of residual beta cells is valuable, as many diabetic patients retain some beta cells. Finding drugs that target and regenerate these cells effectively is a challenge, with no approved options available currently. Nature provides several therapeutic agents, and chicoric acid (CA) found in medicinal plants like Cichorium intybus, and shows potential for beta cell regeneration. Cichorium intybus possesses antioxidants, phenolics, and flavonoids, aiding its antidiabetic activity by targeting hyperglycemia, oxidative stress, inflammation, and hyperlipidemia. CA's multifaceted effects on glucose homeostasis are attributed to its involvement in various interconnected processes and pathways. This comprehensive review explores the molecular-level mechanisms through which chicoric acid facilitates beta cell regeneration, insulin release, and glucose uptake. The findings suggest that chicoric acid holds promise as a phytochemical agent for diabetes prevention and treatment. Its natural origin, antidiabetic properties, and multi-dimensional effects make it a potential candidate. Hence, further research to fully elucidate the efficacy and safety of chicoric acid for β cell regeneration as an antidiabetic agent is essential. In summary, this extensive review at the molecular level, concludes that chicoric acid is a phytochemical with great antidiabetic potential and may be indicated both as a preventive and therapeutic agent. 4 30 2024 105 113 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2024.13204 https://www.phytopharmajournal.com/assets/pdf_files/Vol13_Issue2_04.pdf