none 10.31254/phyto.2023.12504 BioMed Research Publishers BioMed Research Publishers 16195 155559627 316921 20231129193611849 10.31254 2023-11-30T00:36:20Z 2023-11-30T00:36:16Z 0 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://www.phytopharmajournal.com/ 10 30 2023 12 5 Agbangnan Dossa Cokou Pascal https://orcid.org/0000-0002-9093-7731 Daye Efloric Raphaël https://orcid.org/0009-0008-2401-6038 Koudoro Yaya Alain https://orcid.org/0000-0001-9879-5523 Olaye Théophile https://orcid.org/0009-0004-0177-3758 Among the most common health problems worldwide, toothache is often cited and is often treated with herbal medicines to relieve the pain and inflammation associated with it. The present work reports the preliminary phytochemical analysis, antiradical and antibacterial activities of leaves and trunk bark of Pteleopsis suberosa, a plant highly sought after in traditional medicine in Benin to treat toothache. Secondary metabolites were identified by staining and precipitation reactions specific to each metabolite family. Total phenols were determined by the Folin Ciocalteu method. The aluminum trichloride method was used to quantify total flavonoids, while the determination of condensed tannins was carried out by the hydrochloric vanillin method. The antiradical activity of the extracts was evaluated by 2,2-diphenyl-l-picrylhydrazyl and the antibacterial activity by the dilution method in microplates and Petri dishes. Leaves and bark of Pteleopsis suberosa trunk contain tannins, flavonoids, anthocyanins, leuco-anthocyanins, a reducing compound. Ethanol extract of Pteleopsis leaves suberosa (IC 50 =0.0015 μg / μL) showed more interesting anti-radical activity than butylhydroxytoluene (IC 50 =0.012μg/ μL), butylated hydroxyanisole (IC 50 =0.016μg/ μL) and Trolox (IC 50 =0.013 μg/ μL). The ethanolic extract of the bark of the trunk of Pteleopsis suberosa showed bactericidal activity against the Staphylococcus aureus strain. 10 30 2023 299 304 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2023.12504 https://phytopharmajournal.com/assets/pdf_files/Vol12_Issue5_04.pdf