none 10.31254/phyto.2023.12503 BioMed Research Publishers BioMed Research Publishers 16195 155559626 316921 20231129193611849 10.31254 2023-11-30T00:36:19Z 2023-11-30T00:36:16Z 2 The Journal of Phytopharmacology J Phytopharmacol 2320480X 10.31254/phyto https://www.phytopharmajournal.com/ 10 30 2023 12 5 Lusweti Kituyi https://orcid.org/0009-0003-7247-992X Samson M. Lutta https://orcid.org/0009-0006-9956-9441 Steve Barasa https://orcid.org/0000-0003-1116-1523 Artemisia annua L. and Aloe barbadense miller are medicinal plants applied in treatment of various diseases. Staphylococcus aureus is a gram-negative bacterium found commonly on the skin and in the environment. Phytochemical are plants secondary metabolites with promising medicinal properties as remedy to limitations associated with the conventional drugs. A study was conducted to investigate the anti-microbial properties of bioactive components from natural leave extracts of Artemisia annua L. and Aloe barbadensis miller obtained from methanolic as extractant against Staphylococcus aureus. The phytochemical analysis revealed the leave extracts contained most plant secondary metabolites. The biochemical components from both plants were established to inhibit the growth of Staphylococcus aureus. Artemisia annua L had an inhibition zone of 20.67 mm while Aloe barbadensis miller had 10.33 mm against Staphylococcus aureus. The anti-microbial activity of the combined leaves extracts displayed significant high levels of synergetic properties with an inhibition zone of 23.67 mm. Gentamicin which served as standard for the assay had an inhibition zone of 27.67 mm. The study hence showed Artemisia annua L and Aloe barbadensis miller leaves bioactive components can be applied as an effective alternative medicine in management of Staphylococcus aureus. 10 30 2023 295 298 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/phyto.2023.12503 https://phytopharmajournal.com/assets/pdf_files/Vol12_Issue5_03.pdf