none 10.31254/dentistry.2025.10106 BioMed Research Publishers BioMed Research Publishers 16195 179217473 314763 20250711154958356 10.31254 2025-07-11T15:50:03Z 2025-07-11T15:50:00Z 0 International Journal of Dentistry Research Int J Dentistry Res. 25813218 10.31254/dentistry https://dentistryscience.com/ 4 30 2025 10 1 Jonathan Jonas Weng Temporomandibular joint (TMJ) disorders represent a complex group of conditions affecting the jaw joint, leading to functional impairments such as restricted jaw movement, pain, and clicking, as well as aesthetic concerns like facial asymmetry and muscle imbalance. These disorders can significantly impact an individual’s quality of life, making effective treatment essential. While traditional approaches such as physical therapy, medications, and surgical intervention are commonly employed, these methods may not always provide optimal relief, particularly in addressing both the functional and aesthetic aspects of TMJ disorders. In recent years, innovative treatments such as stem cell therapy and Botox (botulinum toxin) injections have emerged as promising alternatives, offering new avenues for managing TMJ disorders. Stem cell therapy has shown potential for regenerating damaged joint tissues, including cartilage and bone, which may help alleviate the root causes of TMJ dysfunction. This regenerative approach aims to restore normal joint function and reduce pain by promoting tissue healing. On the other hand, Botox injections offer symptomatic relief by relaxing the overactive muscles involved in TMJ disorders, reducing muscle tension, and providing short-term pain relief, which can improve jaw movement and facial appearance. This literature review examines the current body of research on the role of stem cell therapy and Botox in treating TMJ disorders, comparing their effectiveness in addressing both the functional limitations and aesthetic issues associated with these conditions. The review includes an analysis of the underlying mechanisms of action, treatment outcomes, and potential risks and benefits. It also explores the implications for clinical practice and patient care, with a focus on patient selection, treatment protocols, and future research directions. By synthesizing current evidence, this paper provides valuable insights into the potential applications of these innovative therapies in managing TMJ disorders. 4 30 2025 25 31 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/dentistry.2025.10106 https://www.dentistryscience.com/IJDR_2025101_06.pdf