none 10.31254/dentistry.2025.10103 BioMed Research Publishers BioMed Research Publishers 16195 179217470 314763 20250711154958356 10.31254 2025-07-11T15:50:02Z 2025-07-11T15:50:00Z 0 International Journal of Dentistry Research Int J Dentistry Res. 25813218 10.31254/dentistry https://dentistryscience.com/ 4 30 2025 10 1 Champilomati Athanasia Kosidou Georgia Molar-incisor hypomineralization (MIH) is a qualitative enamel defect compromising tooth structure, often leading to complications such as caries, hypersensitivity, and extensive restorative treatment needs. This case report discusses a 15-year-old patient with MIH affecting all four first permanent molars, presenting varying degrees of enamel damage. Tooth 36 exhibited pulp necrosis, necessitating endodontic treatment and prosthetic restoration, while conservative approaches were implemented for the other affected molars. The case emphasizes the critical importance of early diagnosis, preventive care, and individualized management strategies to minimize MIH-related complications. A brief literature review explores the etiology, clinical presentation, and management strategies of MIH. The systemic origins and multifactorial nature of MIH, combined with its significant impact on oral health, highlight the necessity for interdisciplinary collaboration in patient care. Further research is required to clarify the condition’s etiology, optimize treatment approaches, and improve clinical outcomes for MIH-affected individuals. 4 30 2025 12 15 1 10.31254/biomed-crossmark-policy www.biomedresearch.org false 10.31254/dentistry.2025.10103 https://www.dentistryscience.com/IJDR_2025101_03.pdf