none 10.31254/dentistry.2021.6209 BioMed Research Publishers BioMed Research Publishers 16195 129090634 314763 20210801032943605 10.31254 2021-08-01T03:29:55Z 2021-08-01T03:29:45Z 0 International Journal of Dentistry Research Int J Dentistry Res 25813218 10.31254/dentistry http://www.dentistryscience.com/ 7 25 2021 6 2 Post-graduate student, Department of Periodontology, Y.M.T Dental College and Hospital, Navi Mumbai, Maharashtra, India Pooja Naik Amit Benjamin Professor, H.O.D and Guide, Department of Periodontology, Y.M.T Dental College and Hospital, Navi Mumbai, Maharashtra, India Shukra Paralkar Post-graduate student, Department of Periodontology, Y.M.T Dental College and Hospital, Navi Mumbai, Maharashtra, India Background and Objectives: Host Modulatory Therapy is a treatment modality for periodontal diseases. It aims at reducing the periodontal destruction and enhances the regenerative capacity of periodontal tissues. Various host modulating agents are used as an adjunct to scaling and root planing. Omega 3 Fatty acids and non-steroidal anti-inflammatory drugs like Aspirin modify the activity of inflammatory mediators and exert anti-inflammatory effect. The objective of the systematic review was to evaluate the effect of Omega 3 Fatty acids plus low dose Aspirin as adjunct to mechanical debridement in reduction of pocket depth in patients with periodontitis. Methods: In this systematic review, Randomized controlled trials in subjects with periodontitis in age group of 25-70 years were considered. Follow up period ranged from 6 weeks to 6 months. A systematic review of literature was performed using Pubmed, PMC, Google scholar, EBSCO host databases. Studies concerning the use of Omega 3 Fatty acids plus low dose Aspirin as host modulating agent in periodontitis treatment were selected. A total 2650 of studies were selected through search strategy and 5 articles which attained the inclusion criteria have been included in present systematic review. Results: Oral supplementation of omega 3 fatty acids in combination of low dose Aspirin as adjunct to mechanical debridement reduces the pocket depth during the 6 weeks to 6 months follow up period. Limitations: There are limited studies which are available. Also there is lack of data evaluating the long term follow up of the intervention. Conclusion: Use of omega 3 fatty acids and low dose aspirin in periodontitis patients improves periodontal status but further long-term studies need to be conducted. 7 25 2021 68 71 10.31254/dentistry.2021.6209 https://www.dentistryscience.com/IJDR_202162_09.pdf