none 10.31254/dentistry.2021.6205 BioMed Research Publishers BioMed Research Publishers 16195 129090630 314763 20210801032943605 10.31254 2021-08-01T03:29:50Z 2021-08-01T03:29:45Z 3 International Journal of Dentistry Research Int J Dentistry Res 25813218 10.31254/dentistry http://www.dentistryscience.com/ 7 25 2021 6 2 Private practice, Danku Mohalla, Khrew, Jammu and Kashmir, 191103, India Gowhar Nazir Josee Amin PG Scholar, RRIUM, Naseem Bagh, Srinagar, Jammu and Kashmir- 190006, India Diabetes mellitus and periodontits are both highly prevalent chronic inflammatory diseases. Both diseases share the same risk factors and are a significant global health care burden adversely affecting the quality of life. Evidence from various studies have demonstrated that diabetes is a major risk factor for periodontal disease and is associated with increased incidence, prevalence and severity of periodontal disease. Hyperglycemia associated with diabetes mellitus results in an increased host immunoinflammatory response which adversely affects the periodontal health. Conversely, periodontits is associated with poor metabolic control in patients with diabetes and increased development of diabetic complications suggesting a bidirectional relationship between the two diseases. Periodontal infection via bacteremia exerts a wide systemic effect by contributing to chronic systemic inflammatory burden worsening diabetic state by increasing insulin resistance. Moreover, studies have demonstrated an improvement in glycemic control following periodontal therapy in prediabetic and diabetic patients with periodontitis. 7 25 2021 43 56 10.31254/dentistry.2021.6205 https://www.dentistryscience.com/IJDR_202162_05.pdf