none 10.31254/dentistry.2020.5210 BioMed Research Publishers BioMed Research Publishers 16195 130548410 314763 20210928110447202 10.31254 2021-09-28T12:03:31Z 2021-09-28T12:03:21Z 0 International Journal of Dentistry Research Int J Dentistry Res. 25813218 10.31254/dentistry http://www.dentistryscience.com/ 8 25 2020 5 2 Department of Periodontics, Faculty of Dentistry, Universitas Hang Tuah Surabaya - Indonesia Hansen Kurniawan Dian Damaiyanti Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah Surabaya - Indonesia Background : Diabetes mellitus (DM) is one of the most common metabolic disorders of high blood sugar levels. Lemuru fish is a resource of pelagic fish that has important economic value. Lemuru fish oil in addition to Omega-3 fatty acids that have been known as anti-inflammatory agent. Objective: To determine the effect of dietary extract of lemuru fish oil on BMP2 levels on periodontal tissue of Wistar rats induced with diabetes mellitus. Materials and Methods: The experiments were conducted with the Post Test Group design. Thirty male Wistar Rats were divided into four groups. Control group, Wistar induced STZ, but not treated. The first group of Wistar induced STZ and given lemuru fish oil extract 4ml / KgBB. The second group, Wistar induced STZ and given lemuru fish oil extract 8ml / KgBB and third group, Wistar induced STZ and given lemuru fish oil extract 16ml / KgBB. Wistar sacrificed. Then examined BMP2 with immunohistochemical methods. All data experiments were analyzed with Mann whitney (p <0.05). Results: The results of this study showed that the control group compared to third group , it was found that in the control group and third group had significant differences. While in second group compared to third group, it was found that in second group and third group did not have significant differences. In first group compared with third group , it was found that in first groups and third group had significant differences. Similarly in second group compared with third group it was found that in second group and third group it was significant difference. From the statistical test it can be seen that in second group compared to third group there was no difference of effect. Conclusion: There was an effect of dietary extract of lemuru fish oil on BMP2 on periodontal tissue of Wistar rats induced by diabetes mellitus. 8 25 2020 76 80 10.31254/dentistry.2020.5210 http://www.dentistryscience.com/IJDR_202052_10.pdf