none 10.1002/ccr3.5140 Wiley Wiley (John Wiley & Sons) 311 132356380 213346 2025112920323300258 10.1002 2025-11-30T04:33:42Z 2021-11-23T02:01:22Z 3 10.1002/ccr3.5186 10.22541/au.162817628.84105856/v1 Clinical Case Reports Clinical Case Reports 2050-0904 2050-0904 11 2021 9 11 10.1002/ccr3.v9.11 https://onlinelibrary.wiley.com/toc/20500904/9/11 Rayan M. Sibira Department of Laboratory Medicine and Pathology Hamad Medical Corporation Doha Qatar https://orcid.org/0000-0002-2468-2371 Ahmed Albakar Urology Department Hamad Medical Corporation Doha Qatar Nagy Younes Urology Department Hamad Medical Corporation Doha Qatar Issam A. Albozom Department of Laboratory Medicine and Pathology Hamad Medical Corporation Doha Qatar Khalid Al Rumaihi Urology Department Hamad Medical Corporation Doha Qatar Abstract Amyloidosis is related to the extracellular deposition of abnormal protein fibrils in various tissues. It can be either localized to an organ or generalized, affecting multiple systems. Amyloidosis of the urinary bladder is a rare histopathological finding. It is clinically interesting that such cases' clinical, radiological, and even endoscopic presentation mimic urothelial carcinoma to a great extent. Here, we discuss a case of a 49‐year‐old gentleman who presented with frank painless hematuria. The patient was diagnosed with a bladder mass suspicious of malignancy depending on the clinical presentation aided by the cystoscopic and radiological evaluation. Histopathologic samples of the transurethral resection of the mass proved to be primary bladder amyloidosis. This case is of unique clinical interest in that it is the first case reported of bladder amyloidosis that is complicated by extraperitoneal bladder rupture post‐operatively. However, no immediate intraoperative perforation to the bladder wall during resection was evidenced. 11 22 2021 11 2021 e05140 10.1002/ccr3.5140 2 10.1002/crossmark_policy onlinelibrary.wiley.com true 2021-08-02 2021-11-14 2021-11-22 http://creativecommons.org/licenses/by/4.0/ 10.1002/ccr3.5140 https://onlinelibrary.wiley.com/doi/10.1002/ccr3.5140 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.5140 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.5140 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.5140 10.14797/mdcj-8-3-3 10.4065/75.12.1264 10.1016/j.humpath.2019.08.011 10.1159/000506696 10.1146/annurev-pathol-020712-163913 10.4103/0377-4929.42547 10.1007/s00330-002-1793-4 Am J Clin Exp Urol Zhou F 71 2 1 2014 Primary localized amyloidosis of the urinary tract frequently mimics neoplasia: a clinicopathologic analysis of 11 cases